This peer-reviewed review highlights the traditional and modern applications of *Morinda citrifolia* (commonly known as noni), especially its growing role as a functional food and botanical remedy. Originating from the tropics, noni has been used for centuries in Polynesian and Southeast Asian medicine. The fruit, leaves, roots, and seeds contain more than 200 bioactive compounds, including antioxidants, flavonoids, anthraquinones, lignans, and iridoids. These phytochemicals have been shown in laboratory and animal studies to exhibit antibacterial, antifungal, antiviral, anti-inflammatory, analgesic, and even anti-cancer properties. Industrial uses now span natural preservatives, juice and probiotic beverages, green insecticides, and chemical reagents. Research has also explored the use of noni extracts in nanotechnology and bioreactor-based pharmaceutical production.
Preclinical and early clinical trials have explored noni’s potential in treating infections, arthritis, diabetes, cancer, memory loss, and even obesity. One notable study showed that Tahitian noni juice significantly reduced DNA damage in heavy smokers, while others reported promising anti-cancer and anti-inflammatory effects in both lab and animal models. Despite these encouraging findings, researchers emphasize the need for more rigorous human clinical trials to confirm safety, dosage, and efficacy. The chemical composition and therapeutic effects of noni can vary significantly by geography, variety, and processing method—highlighting the importance of quality control in commercial products.
*Published in the Arabian Journal of Chemistry, 2017.* http://creativecommons.org/licenses/by-nc-nd/4.0/
**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.**