This study investigates the pulmonary anti-inflammatory effects of Morinda citrifolia (noni) fruit juice in a controlled animal model. Researchers used mice with lipopolysaccharide (LPS)-induced acute lung inflammation, a model that mimics the inflammatory response seen in conditions like acute respiratory distress syndrome. Mice that received noni juice orally for one week prior to LPS exposure showed significantly reduced lung inflammation, as evidenced by fewer infiltrating neutrophils and lower levels of inflammatory cytokines (TNF-α and IL-6) in the bronchoalveolar lavage fluid. Histological examination also confirmed that noni treatment attenuated tissue damage in the lungs.
The findings suggest that noni juice exerts its protective effects by modulating inflammatory signaling pathways, notably by suppressing NF-κB activation, a key driver of inflammation. This mechanism supports the traditional use of noni for respiratory ailments and provides a scientific basis for its potential application in managing lung inflammation. The authors conclude that noni juice may have therapeutic value as a natural anti-inflammatory agent, particularly in inflammatory pulmonary conditions.
Journal of Ethnopharmacology 192 (2016) 264–272, www.elsevier.com/locate/jep
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