A study published in 2022 evaluated the antioxidant and antiproliferative properties of ethanol and ethyl acetate extracts of *Morinda citrifolia* (noni) fruit. Using a DPPH assay to measure free radical scavenging capacity, researchers found that both extracts exhibited substantial antioxidant activity, with the ethyl acetate extract showing the strongest effect (IC50 = 44.8 μg/mL). The antiproliferative effects were tested on HeLa (cervical cancer) and A549 (lung cancer) cell lines, revealing dose-dependent growth inhibition—again, with the ethyl acetate extract proving more effective than ethanol. Phytochemical screening confirmed the presence of beneficial compounds such as phenols, flavonoids, alkaloids, saponins, and glycosides, which are known contributors to anticancer and antioxidant activity.
The study concluded that noni fruit extracts could be developed into natural therapeutic agents to combat oxidative stress and reduce the growth of cancer cells. The findings also suggest that ethyl acetate may be the optimal solvent for extracting the bioactive compounds responsible for these benefits. These results support a growing body of research validating the traditional use of noni fruit in herbal medicine and highlight its potential as a plant-based supplement for promoting cellular health and protecting against degenerative diseases.
*Published in the International Journal of Pharmaceutical Sciences and Research (IJPSR), Vol. 13, Issue 12, December 2022. https://doi.org/10.33745/ijzi.2022.v08i02.014
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