A 2022 study evaluated the anticancer potential of *Morinda citrifolia* (noni) fruit extracts on human hepatocellular carcinoma (HepG-2) cell lines, revealing powerful cytotoxic and antioxidant effects. The methanolic extract demonstrated the strongest anticancer activity, achieving 50% inhibition of cancer cell growth (IC50) at a concentration of 71.442 µg/ml, significantly outperforming both aqueous and chloroform extracts. The study found that noni fruit is rich in bioactive phytochemicals such as flavonoids, anthocyanins, terpenoids, alkaloids, and steroids—all known to contribute to its anti-tumor effects. Morphological studies showed that treated cancer cells exhibited significant disintegration and cell death, further supporting the extract’s pro-apoptotic (cell-death-inducing) properties.
Researchers also noted that noni extract could promote apoptosis—the natural death of cancerous cells—through activation of key proteins such as caspase-3 and caspase-8. These findings align with previous studies suggesting noni’s antioxidant properties can reduce oxidative stress and DNA damage, both of which play major roles in cancer development. This research supports the growing interest in using noni fruit as a natural, plant-based supplement for managing cancer risk and potentially aiding in treatment, especially in drug-resistant forms of the disease.
*Published in the International Journal of Zoological Investigations, Vol. 8, No. 2, July 2022. [https://doi.org/10.33745/ijzi.2022.v08i02.014](https://doi.org/10.33745/ijzi.2022.v08i02.014)*
**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.**
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